Studies on Collagen Complete’s Ingredients


Hydrolyzed Collagen Studies

  1. Collagen structure
  2. Collagen assimilation
  3. Collagen and skin
  4. Collagen and joints
  5. Collagen and bone density

Hyaluronic Acid Studies
Glucosamine & Chondroitin Studies

“Hydrolyzed collagen contains 20 amino acids, predominantly glycine, proline and hydroxyproline.”

Study

“What is hydrolyzed collagen?” Rousselot. July 2009.


“More than 90% of hydrolyzed collagen is absorbed within 6 hours of ingestion. An important part is accumulated in cartilage and skin.”

Study

Oesser, S., et al. (1999). “Oral administration of 14C labelled gelatine hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL)”. Journal of nutrition 129 (10): 1891–1895. PMID 10498764.

“Hydrolyzed collagen is absorbed in small peptides in the blood.”

Study

Iwai, K., et al (2005). “Identification of food-derived collagen peptides in human blood after oral ingestion of gelatinehydrolysates”. Journal of agriculture and food chemistry 53 (16): 6531–6536. 16076145.


“Orally ingested hydrolyzed collagen increases the density of collagen in the skin.”

Study

Matsuda, N., et al. (2006). “Effectsof ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis”. Journal of nutritionvitaminology 52 (3): 211–215. doi:10.3177/jnsv.52.211.

“After 8 weeks, hydrolyzed collagen results in significant improvements of skin elasticity, moisture, and smoothness.”

Study

Skin Pharmacol Physiol. 2014;27(1):47-55. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. PMID 23949208

“Hydrolyzed collagen results in significant improvement in wrinkle depth, improvement in elasticity and hydration of the skin.”

Study

Borumand M, Sibilla S. Effects of a nutritional supplement containing collagen peptides on skin elasticity, hydration and wrinkles. J Med Nutr Nutraceut 2015;4:47-53 JMNN.ORG

“Hydrolyzed collagen prevents skin damage from UVA and UVB sunlight exposure.”

Study

Midori TANAKA, et al. Effects of Collagen Peptide Ingestion on UV-B-Induced Skin Damage tandfonline.com

“Hydrolyzed collagen ingestion increases skin collagen types I and IV, and potentially reduces aging changes in skin.”

Study

Matsumoto et al (2006) Clinical effect of fish type I collagen hydrolysate on skin properties. ITE Lett Batteries New Technol Med 2006;7:386-390

“Experiments demonstrated that collagen peptides induce collagen as well as glycosaminoglycan production. The oral supplementation with collagen peptides is efficacious to improve hallmarks of skin aging.”

Study

J Cosmet Dermatol The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network.

“Collagen peptide ingestion results in more collagen-producing cells and increases the density of collagen in the skin.”

Study

Matsumoto et al (2006), Clinical effects of fish type I collagen hydrolysate on skin properties. ITE Letters on Batteries, New Technologies & Medicine, 7: 386-390


“The results of the study demonstrated that a regular ingestion of [hydrolyzed collagen] over a period of 6 months led to a clear improvement of the skin appearance in women suffering from moderate cellulite.”


“10g of hydrolyzed collagen per day decreases joint pain, especially for those with the most severe symptoms.”

Study

Moskowitz, R.(2000). “Role of collagen hydrolysate in bone and joint disease.” Seminars in arthritis and rheumatism 30(2): 87-89

Study

Ruiz-Benito, et al. (2009). “A randomized controlled trial on theefficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort”. International journal of foodscience and nutrition 12: 1–15.

“24 weeks of hydrolyzed collagen use significantly reduced joint pain in a study of 147 athletes.”

Study

Clark K.L. et al. (2008). 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current Medical Research and Opinion, 24(5):PMID 18416885

Knee Joint Study (Placebo Group):collagen for joints placebo day 1joint collagen study week 24joint collagen study placebo week 48

Knee Joint Study (Collagen Group):joint collagen studyjoint collagen studyCollagen group week 48

Study

“These preliminary results suggest that the dGEMRIC technique may be able to detect change in proteoglycan content in knee cartilage among individuals taking collagen hydrolysate after 24 weeks.” Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate.


“10g of hydrolyzed collagen for 4 to 24 weeks increases bone mass density.”

Study

[7]  Nomura,Y.; Oohashi, K, Watanabe et al. “Increase in bone density through oral administration of hydrolyzed collagen.” S. Nutrition 21(11-12): 1120-1126 PMID 16308135.

Study

Wu, J., et al. (2004). “Increase of effectiveness of oral administrationof collagen peptide on bone metabolism in growing and mature rats”. Bone and mineral metabolism 22 (6): 547–553. PMID 15490264.

“Hydrolyzed collagen strengthens bones by stimulating the creation of bone-forming cells (osteoblasts).”

Study

Guillerminet, et al. Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: an in vitro and in vivo study. PMID 19895915.

Study

Bovine collagen peptides compounds promote the proliferation and differentiation of MC3T3-E1 pre-osteoblasts.  Liu, Zhang, Song, Ma, Si, Wang, Xu, Feng, Wu, Guo.  PMID 24926875  

“The loss of whole body bone mineral density in women taking CC was substantially lower than that of the control group at 12 months in those who completed the study.”


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Hyaluronic Acid:

“Hyaluronic acid cocktail leads to a significant improvement in wrinkle depth, improvement in elasticity and hydration of the skin.”

Study

Borumand M, Sibilla S. Effects of a nutritional supplement containing collagen peptides on skin elasticity, hydration and wrinkles. J Med Nutr Nutraceut 2015;4:47-53 JMNN.ORG

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Glucosamine & Chondroitin Studies:

“Glucosamine stimulates Hyaluronic Acid production, which decreases wrinkles, improves skin hydration and accelerates wound healing.”

Study

Bissett DL1. Glucosamine: an ingredient with skin and other benefits. J Cosmet Dermatol. 2006 Dec;5(4):309-15. PMID 17716251

“Oral glucosamine supplementation results in 34% reduction in wrinkles.”

Study

Murad H1, Tabibian MP. The effect of an oral supplement containing glucosamine, amino acids, minerals, and antioxidants on cutaneous aging: a preliminary study. J Dermatolog Treat. 2001 Mar;12(1):47-51. PMID 12171689

“Glucosamine is helpful in reducing symptoms of moderate to severe osteoarthritis and slowing the progression of osteoarthritis.”

Study

Bruyere O1, Reginster JY. Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis. Drugs Aging. 2007;24(7):573-80. PMID 17658908

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